湖南科技大学化学化工学院首页

导师简介：
陈建，男，湖南沅江人，博士（后），教授，研究生导师，湖南科技大学教育部重点实验室专职科研人员。中国化学会会员、湖南省化学化工学会会员。近年来，先后共主持各类科研项目10来项，其中包括国家自然科学基金课题3项，教育部留学回国人员启动基金课题1项，省自然科学基金课题1项，省教育厅优秀青年项目1项、中国博士后基金课题2项等。2010年获广东省优秀博士学位论文，2011年获全国优秀博士学位论文提名奖，2014年获湖南省化学化工学会第十三届青年化学化工奖。在《Advanced Functional Materials》、《Small》、《Macromolecules》、《Chemical Communications》、《Polymer Chemistry》等国内外杂志上发表SCI论文60余篇，他引1000余次，其中ESI高被引论文3篇，H指数为21。申请发明专利20余项，授权14项。

联系方式：

Email: cj920@foxmail.com

主持的科研或教研项目：

[1]国家自然科学基金面上项目：具有基因载体功能的光开关近红外荧光聚合物纳米材料设计合成与生物成像研究（No. 51773056），2018-2021；

[2]国家自然科学基金面上项目：水分散性荧光聚合物量子点设计合成及多色可调光开关研究（No. 51373002），2014-2017；

[3]国家自然科学基金青年项目：新型两亲性多色荧光聚合物纳米粒子的设计合成及FRET研究（No. 51003026），2011-2013；

[4]中国博士后科学基金特别资助项目：荧光聚合物量子点构建与硫离子比率荧光检测及成像研究(No. 2015T80867)， 2015-2016；

[5]中国博士后科学基金项目：新型荧光聚合物量子点制备与汞离子荧光比率检测应用（第55批面上一等资助，No. 2014M550418），2014-2015；

[6]教育部留学回国人员科研启动基金：基于共轭聚合物的光开关荧光纳米材料设计及FRET研究， 2014-2016；

[7]湖南省教育厅优秀青年基金：新型两亲性光开关荧光聚合物纳米粒子设计合成与优化，（No. 12B041），2012-2014；

[8]湖南省自然科学基金青年项目：聚合物纳米粒子中荧光共振能量转移体系的构建与优化（No. 11JJ4016），2011-2013；

发表的主要论文：

1.Hong Wang1, Yanyang He1, Yuqi Li, Chonghua Zhang, Peisheng Zhang*, Jiaxi Cui, Yunfei Long, Shu Chen, Rongjin Zeng, Jian Chen*, Selective ratiometric fluorescence detection of hypochlorite by using aggregation-induced emission dots. Analytical and Bioanalytical Chemistry, 2019, DOI: 10.1007/s00216-019-01653-0.

2.Maolin Yu, Hong Wang, Yuqi Li, Peisheng Zhang*, Shu Chen, Rongjin Zeng, Yong Gao*, Jian Chen*, Photoswitchable diarylethene-based polyurethane film for photorewritable patterning and stable information storage. Journal of Applied Polymer Science 2019, 136(20): 47466.

3.Yongxiang Hong, Hong Wang, Mingju Xue, Peisheng Zhang*, Wanqiang Liu, Shu Chen, Rongjin Zeng, Jiaxi Cui, Yong Gao*, and Jian Chen*, Rational design of a ratiometric and lysosome-targetable AIE dots for imaging endogenous HClO in live cells. Materials Chemistry Frontiers 2019, 3: 203-208.

4.Mingju Xue1, Hong Wang1, Jian Chen*, Junyu Ren, Shu Chen, Heping Yang, Rongjin Zeng, Yunfei Long and Peisheng Zhang*, Ratiometric fluorescent sensing of endogenous hypochlorous acid in lysosomes using AIE-based polymeric nanoprobe. Sensors and Actuators B 2019, 282: 1-8.

5.Chong-Hua Zhang, Hong Wang, Jin-Wen Liu, Ying-Ying Sheng, Jian Chen*, Peisheng Zhang, Jian-Hui Jiang*, Amplified Split Aptamer Sensor Delivered Using Block Copolymer Nanoparticles for Small Molecule Imaging in Living Cells. ACS Sensors 2018, 3, 2526−2531.

6.Maolin Yu1, Peisheng Zhang1, Baiju P. Krishnan, Hong Wang, Yong Gao*, Shu Chen, Rongjin Zeng, Jiaxi Cui*, and Jian Chen*, From a Molecular Toolbox to a Toolbox for Photoswitchable Fluorescent Polymeric Nanoparticles. Advanced Functional Materials, 2018, 28: 1804759.

7.Hong Wang1, Peisheng Zhang1, Baiju P. Krishnan, Maolin Yu, Jie Liu, Mingju Xue, Shu Chen, Rongjin Zeng, Jiaxi Cui* and Jian Chen*, Switchable single fluorescent polymeric nanoparticles for stable white-light generation. Journal of Materials Chemistry C, 2018, 6: 9897-9902.

8.Peisheng Zhang*, Yong Tian, Hui Liu, Junyu Ren, Hong Wang, Rongjin Zeng, Yunfei Long and Jian Chen, In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor, Chemical Communications, 2018, 54: 7231-7234.

9.Hong Wang, Peisheng Zhang*, Yong Tian, Yuan Zhang, Heping Yang, Shu Chen, Rongjin Zeng*, Yunfei Long, Jian Chen*. Real-time monitoring of endogenous cysteine levels in living cells using a CD-based ratiometric fluorescent nanoprobe. Analytical and Bioanalytical Chemistry, 2018, 410: 4379-4386.

10.Yongxiang Hong, Peisheng Zhang*, Hong Wang, Maolin Yu, Yong Gao*, Jian Chen*. Photoswitchable AIE nanoprobe for lysosomal hydrogen sulfide detection and reversible dual-color imaging. Sensors and Actuators B 2018, 272: 340-347.

11.Peisheng Zhang, Hong Wang, Di Zhang, Xuyao Zeng, Rongjin Zeng,* Lehui Xiao*, Hongwen Tao Yunfei Long, Pinggui Yi, and Jian Chen*. Two-photon fluorescent probe for lysosome-targetable hypochlorous acid detection within living cells. Sensors and Actuators B 2018, 255: 2223-2231.

12.Peisheng Zhang*, Hong Wang, Yongxiang Hong, Maolin Yu, Rongjin Zeng, Yunfei Long, Jian Chen*. Selective visualization of endogenous hypochlorous acid in zebrafish during lipopolysaccharide-induced acute liver injury using a polymer micelles-based ratiometric fluorescent probe. Biosensors and Bioelectronics 2018, 99: 318–324.

13.Peisheng Zhang,1 Yongxiang Hong,1 Hong Wang, Maolin Yu, Yong Gao,*, Rongjin Zeng,* Yunfei Long and Jian Chen*. Selective visualization of endogenous hydrogen sulfide in lysosomes via using aggregation induced emission dots. Polymer Chemistry 2017, 8: 7271 - 7278.

14.Jian Chen,* Weibang Zhong, Mingju Xue, Hong Wang, Maolin Yu, Peisheng Zhang* and Pinggui Yi*. Photochromic RAFT reagent helps constructing superior photoswitchable fluorescent polymer nanoparticles for rewritable fluorescence patterning and intracellular dual-color imaging. Polymer Chemistry 2017, 8: 6520-6526.

15.Hong Wang, Peisheng Zhang,* Yongxiang Hong, Bin Zhao, Pinggui Yi and Jian Chen*. Ratiometric imaging of lysosomal hypochlorous acid enabled by FRET-based polymer dots. Polymer Chemistry 2017, 8: 5795-5802.

16.Weibang Zhong1, Xuyao Zeng1, Jian Chen*, Yongxiang Hong, Lehui Xiao and Peisheng Zhang*. Photoswitchable ﬂuorescent polymeric nanoparticles for rewritable ﬂuorescence patterning and intracellular dual-color imaging with AIE-based ﬂuorogens as FRET donors. Polymer Chemistry 2017, 8: 4849-4855.

17.Jian Chen*, Chonghua Zhang, Kun Lv, Hong Wang, Peisheng Zhang*, Pinggui Yi, Jianhui Jiang*. A silica nanoparticle-based dual-responsive ratiometric probe for visualizing hypochlorite and temperature with distinct fluorescence signals. Sensors and Actuators B 2017, 251: 533-541.

18.Jian Chen, Adam W. Ziegler, Baoming Zhao, Wei Wan and Alexander D. Q. Li*. Chemomechanical-force-induced folding–unfolding directly controls distinct fluorescence dual-color switching. Chemical Communications, 2017, 53, 4993-4996.

19.Hong Wang1, Peisheng Zhang1, Jian Chen*, Ya Li, Maolin Yu, Yunfei Long, Pinggui Yi. Polymer nanoparticle-based ratiometric fluorescent probe for imaging Hg2+ ions in living cells. Sensors and Actuators B 2017, 242: 818-824.

20.Kun Lv, Jian Chen*, Hong Wang, Peisheng Zhang*, Maolin Yu, Yunfei Long, Pinggui Yi. One-pot fabrication of FRET-based fluorescent probe for detecting copper ion and sulfide anion in 100% aqueous media. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2017, 177, 63-68.

21.Hong Wang, Jian Chen*, Yongxiang Hong, Kun Lv, Maolin Yu, Peisheng Zhang*, Yunfei Long, and Pinggui Yi. Fabrication of Water-soluble Fluorescent Polymeric Micelles for Selective Detection of Hg2+ in Blood Serum. Analytical Sciences 2017, 33, 591-597.

22.Jian Chen*, Ying Tang, Hong Wang, Peisheng Zhang*, Ya Li and Jianhui Jiang*. Design and fabrication of fluorescence resonance energy transfer-mediated fluorescent polymer nanoparticles for ratiometric sensing of lysosomal pH, Journal of Colloid and Interface Science 2016, 484: 298-307.

23.Jian Chen*, Ya Li, Kun lv, Weibang Zhong, Hong Wang, Zhan Wu*, Pinggui Yi* and Jianhui Jiang. Cyclam-Functionalized Carbon Dots Sensor for Sensitive and Selective Detection of Copper(II) Ion and sulfide anion in Aqueous Media and Its Imaging in Live Cells. Sensors and Actuators B 2016, 224: 298-306.

24.Jian Chen,* Ya Li, Weibang Zhong, Hong Wang, Peisheng Zhang* and Jianhui Jiang. A highly selective fluorescent and colorimetric chemosensor for Hg2+ based on a new rhodamine derivative. Analytical Methods 2016, 8: 1964-1967.

25.Jian Chen,* Weibang Zhong, Ying Tang, Zhan Wu, Ya Li, Pinggui Yi,* Jianhui Jiang*. Amphiphilic BODIPY-Based Photoswitchable Fluorescent Polymeric Nanoparticles for Rewritable Patterning and Dual-Color Cell Imaging. Macromolecules 2015, 48: 3500-3508.

26.Jian Chen*, Ya Li, Weibang Zhong, Qingyang Hou, Hong Wang, Xiang Sun and Pinggui Yi. Novel fluorescent polymeric nanoparticles for highly selective recognition of copper ion and sulfide anion in water. Sensors and Actuators B 2015, 206: 230-238.

27.Jian Chen*, Fuhua Huang, Hong Wang, Ya Li, Shengli Liu, Pinggui Yi. One-pot preparation of multicolor polymeric nanoparticles with high brightness by single wavelength excitation. Journal of Applied Polymer Science 2015, 132: 41492.

28.Bo Liao*, Peng Long, Benqiao He*, Shoujun Yi, Baoli Ou, Shaohua Shen, Jian Chen*. Reversible Fluorescence Modulation of Spiropyrans-functionalized Carbon Nanoparticles. Journal of Materials Chemistry C 2013, 1: 3716-3721.

29.Peisheng Zhang, Jian Chen*, Fuhua Huang, Zhiqiang Zeng, Jia Hu, Pinggui Yi*, Fang Zeng and Shuizhu Wu. One-pot fabrication of polymer nanoparticle-based chemosensor for Cu2+ detection in aqueous media. Polymer Chemistry 2013, 4: 2325-2332.

30.Jian Chen*, Dapeng Wang, Andrey Turshatov, Rafael Muñoz-Espí, Ulrich Ziener,* Kaloian Koynov, Katharina Landfester*. One-pot Fabrication of Amphiphilic Photoswitchable Thiophene-Based Fluorescent Polymer Dots. Polymer Chemistry 2013, 4: 773-781.

31.Jian Chen, Jie Shu, Simone Schobloch, Anja Kroeger, Robert Graf, Rafael Muñoz-Espí, Katharina Landfester, and Ulrich Ziener*. A New Design Strategy for the Synthesis of Unsubstituted Polythiophene with Deﬁned High Molecular Weight. Macromolecules 2012, 45: 5108-5113.

32.Jian Chen*, Peisheng Zhang, Gang Fang, Chao Weng, Jia Hu, Pinggui Yi*, Xianyong Yu and Xiaofang Li. One-pot synthesis of amphiphilic reversible photoswitchable ﬂuorescent nanoparticles and their ﬂuorescence modulation properties. Polymer Chemistry 2012, 3: 685-693.

33.Jian Chen*, Peisheng Zhang, Gang Fang, Pinggui Yi*, Fang Zeng and Shuizhu Wu. Design and Synthesis of FRET-Mediated Multicolor and Photoswitchable Fluorescent Polymer Nanoparticles with Tunable Emission Properties. Journal of Physical Chemistry B 2012, 116(14):4354-4362.

34.Jian Chen, Peisheng Zhang, Gang Fang, Pinggui Yi*, Xianyong Yu, Xiaofang Li, Fang Zeng* and Shuizhu Wu. Synthesis and Characterization of Novel Reversible Photoswitchable Fluorescent Polymeric Nanoparticles via One-Step Miniemulsion Polymerization. Journal of Physical Chemistry B 2011, 115(13): 3354-3362.

授权发明专利：

[1].陈建, 李亚, 黄富华, 孙祥, 王宏, 一种具有铜离子和硫阴离子双识别功能的水分散性荧光聚合物纳米粒子及其制备方法和应用, 发明专利, 授权专利号: ZL201310322589.2。

[2].陈建, 钟维邦, 孙祥, 李亚, 候庆扬, 易平贵, 一种检测汞离子的两亲性聚合物纳米粒子、制备方法及应用, 发明专利, 授权专利号: ZL201410061992.9。

[3].陈建, 钟维邦, 李亚, 吕锟, 李明莉, 廖博, 易平贵, 一种两亲性光开关荧光聚合物纳米粒子及其制备方法, 发明专利, 授权专利号: ZL201410352430.X。

[4].陈建, 王宏, 李亚, 侯庆杨, 吕锟, 吉添, 李明莉, 周智华, 易平贵,一种具有pH值和汞离子比率检测功能的水分散性荧光聚合物纳米粒子、制备方法及应用, 发明专利, 授权专利号: ZL201410369075.7。

[5].陈建, 李亚, 钟维邦, 吕锟, 王宏, 廖博, 易平贵, 一种具有铜离子和半胱氨酸双识别功能的碳量子点传感器及其制备方法和应用, 发明专利, 授权专利号: ZL201410610062.4。

[6].陈建, 李亚, 王宏, 钟维邦, 吕锟, 侯庆阳, 易平贵, 一种具有硫离子、铜离子和pH值多重检测功能的荧光传感器制备方法及应用, 发明专利, 授权专利号: ZL201510001105.3。

[7].陈建, 钟维邦, 李亚, 吕锟, 王宏, 廖博, 易平贵, 两亲性多色光开关荧光聚合物纳米粒子及其制备方法, 发明专利, 授权专利号: ZL201410776223.7。

[8].陈建, 李亚, 钟维邦, 吕锟, 王宏, 侯庆阳, 易平贵, 基于罗丹明衍生物的比色汞离子传感器的制备方法及应用, 发明专利, 授权专利号: ZL201410776232.6。

[9].陈建、李亚、王宏、钟维邦、吕锟、洪永想、易平贵，一种基于聚乙二醇的硫离子传感器及其制备方法和应用，发明专利, 授权专利号: ZL201510413193.8。

[10].陈建、吕锟、洪永想、钟维邦、王宏、易平贵，一种具有多识别功能的荧光聚合物及其制备方法和应用，发明专利, 授权专利号: ZL201510425158.8。