基本情况
姓名：李毅
性别：男
出生年月：1986-09
籍贯：湖南邵阳
职位：理学博士，副教授，硕士生导师
邮箱：yli@hnust.edu.cn
教育及工作经历
2018.12—至今 湖南科技大学 副教授
2017.07—2018.12 湖南科技大学 助理研究员
2015.01—2017.07 中山大学 基础医学博士后流动站 博士后/助理研究员
2009.09—2014.12 中山大学 化学与化学工程学院 理学博士
2005.09—2009.06 吉首大学 化学化工学院 理学学士
讲授课程
《普通化学》、《无机化学实验》
科研方向
过渡金属配合物的抗肿瘤及生物成像
科研项目
[1] 国家自然科学基金青年基金，21601210，2017.01-2019.12，20万。
[2] 湖南省自然科学基金青年基金，2019JJ50188，2019.01-2021.12，5万。
[3] 湖南科技大学博士启动基金项目，E51880，2018.04-2020.12，5万。
[4] 湖南省教育厅科研项目，18C0340，2018.09-2020.12，1万。
[5] 中国博士后科学基金，2015M572397，2015.01-2016.12，5万。
主要论文
[1] Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agents. Biomaterials 2015, 39, 95-104.
[2] Yi Li, Kang-Nan Wang, Liang He, Liang-Nian Ji and Zong-Wan Mao*, Synthesis, photophysical and anticancer properties of mitochondria-targeted phosphorescent cyclometalated iridium(III) N-heterocyclic carbene complexes. J. Inorg. Biochem., 2020, 205, 110976.
[3] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Mitochondria-targeted two-photon fluorescent probe for the detection of biothiols in living cells. Sensors and Actuators B: Chemical 2018, 255, 193-202.
[4] Yi Li, Kang-Nan Wang, Bing Liu, Xin-Ran Lu, Meng-Feng Li,* Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) N-heterocyclic carbene complexes as potential mitochondrial anticancer and photodynamic agents. Dalton Trans ., 2017, 46, 11363-11371.
[5] Yi Li, Gao-Feng Liu,* Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Antitumor properties and mechanisms of mitochondria-targeted Ag(I) and Au(I) complexes containing N-heterocyclic carbenes derived from cyclophanes. Metallomics 2014, 6, 1460-1468.
[6] Liang He, Yi Li, Cai-Ping Tan,* Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji and Zong-Wan Mao*, Cyclometalated iridium(III) complexes as lysosome targeted photodynamic anticancer and real-time tracking agents. Chem. Sci. , 2015, 6, 5409-5418.
[7] Qian Cao, Yi Li, Eva Freisinger, Peter Z. Qin,* Roland K. O. Sigel,* and Zong-Wan Mao*, G-Quadruplex DNA Targeted Metal Complexes Acting as Potential Anticancer Drugs. Inorg. Chem. Front., 2017, 4, 10-32.
[8] Wei Zhang, Yi Li, Jing-Hua Sun, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*, Supramolecular self-assembled nanoparticles for chemo-photodynamic dual therapy against cisplatin resistant cancer cells. Chem. Commun. , 2015, 51, 1807-1810.
[9] Jin-Tao Wang, Yi Li, Jia-Heng Tan, Liang-Nian Jia and Zong-Wan Mao*, Platinum(II)-triarylpyridines complexes with electropositive pendants as efficient G-quadruplex binders. Dalton Trans ., 2011, 40, 564-566.
[10] Wei-Wei Qin, Zheng-Yin Pan, Daihong Cai, Yi Li and Liang He. Cyclometalated iridium(III) complexes for mitochondria-targeted combined chemo- photodynamic therapy. Dalton Trans ., 2020, 10.1039/D0DT00180E.
[11] Cuixia Xu Hui Yang, Yi Li, Jianwei Wang, Xihong Lu. Surface Engineering for Advanced Aqueous Supercapacitors: A Review. ChemElectroChem ., 2020, 7, 586–593.
[12] Liang He, Ming-Fang Zhang, Zheng-Yin Pan, Kang-Nan Wang, Zi-Jian Zhao, Yi Li and Zong-Wan Mao. A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. Chem. Commun ., 2019, 55, 10472-10475.
[13] Liang He, Zheng-Yin Pan, Wei-Wei Qin, Yi Li, Cai-Ping Tan and Zong-Wan Mao. Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(I) complex. Dalton Trans ., 2019, 48, 4398-4404.
[14] Fangfang Wang, Yanmei Sun, Xiaohua Liu, Yi Li, Lifeng Tan. Third-strand stabilizing effects of the RNA poly(U)·poly(A)*poly(U) triplex by a ruthenium(II) polypyridine complex and its hexaarginine peptide conjugate. I nt. J B iol. M acromol ., 2019, 135, 1134–1141.
[15] Zanru Tan, Juan Zhu, Wen Ni, Xiaohua Liu, Yi Li, Lifeng Tan. Binding properties of two ruthenium(II) polypyridyl complexes [Ru(bpy)2(dppz-Br)]2+ and [Ru(dmb)2(dppz‑Br)]2+ with the RNA poly(U)•poly(A)*poly(U) triplex. J . B iol. I norg. C hem. , 2019, 24, 721-731.
