谢文林，男，1967年生，博士，教授，博士生导师。主要从事新型抗肿瘤药物的设计、合成和分子机理研究以及葡萄糖苷酶、乙酰胆碱酯酶等酶抑制剂的设计合成和活性筛选。近年来主持国家自然科学基金面上项目1项、湖南省自然科学基金等省部级项目8项、药物研发横向课题4项。获湖南省自然科学三等奖一项，获省部级教学成果二等奖、三等奖各1项，指导研究生获湖南省第八届研究生创新论坛优秀论文一等奖1项，指导学生获湖南省第七届大学生创新作品竞赛二等奖1项。在Chem. Commum.、Org.Chem.Front.、Adv. Synth. Catal., J. Org. Chem., Eur. J. Med. Chem., Bioorg. Med. Chem. Lett., Org. Biomol. Chem., Chem. Biol. Drug Des.和化学学报等国内外重要刊物上共发表学术论文50余篇，SCI收录30余篇。申请中国发明专利12项，授权8项。
联系方式：Email: xwl2000zsu@163.com
研究方向：
1、类天然有机小分子的设计与合成；
2、药物分子的设计、合成与生物活性研究；
主持课题：
1. 以G-四链体为靶的Isatin衍生物及其金属配合物的合成和抗癌作用，国家自然科学基金(No. 21571058)，2016,01-2019,12。70.0万元
2. 以拓扑异构酶为靶含噻唑环的吡啶酮新型衍生物的合成及抗肿瘤活性研究，2014湖南省自然科学基金(No.2015JJ4026),2015,01-2018,12。2.0万元
3. 基于纺锤体驱动蛋白新型二氢嘧啶衍生物的合成及抗肿瘤活性研究，湖南省教育厅重点项目(No.22A0348), 2023-2025。4.0万元
4.以G-quadruplex为靶的吲哚-2,3-二酮新型衍生物的合成和抗癌作用，湖南省高校创新平台开放基金项目(No.17K032), 2017,09-2020,12。6.0万元
5. 5,6-二取代吡啶二酮缩氨基硫脲新型衍生物的合成及抗肿瘤活性研究，湖南省科技计划项目(No.2013SK3161), 2013.07-2015.12。 3.0万元
代表性论文：
1. Rui Qi, Tianwen Bai, Shuwang Tang, Ming Hou, Zhide Zhang, Wenlin Xie*,Yangling Deng, Hongwei Zhou* and Guanyinsheng Qiu*, Solvent-promoted photochemical carbonylation of benzylic C–H bonds under iron catalysis, Org. Biomol. Chem., 2023, 21, 5382–5386
2. Feng Pan, Huilin Xie, Wenlin Xie*, Yu-Chao Wang, Jin-Biao Liu*, Guanyinsheng Qiu*, Selenium Radical-Triggered Spiro-tricyclization of N -Aryl- N -(2-hydroxyethyl)propiolamide, Synthesis, 2022, 54, 3105-3113
3. Xuelian Zhao,Xuehui Zhan, Huilin Zhang, Yichao Wan, Huizhong Yang, Yutian Wang, Yanda Chen, Wenlin Xie*,Synthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors, Bioorg. Med. Chem. Lett., 2021, 54, 128447
4. Yanfang Yao, Ziqing Yin, Fu-Sheng He*, Xuwei Qin, Wenlin Xie* And Jie Wu*, Photoinduced intramolecular carbosulfonylation of alkynes: access to sulfone-containing dibenzazepines from sulfur dioxide, Chem. Commun., 2021, 57, 2883-2886
5. Xiaodong Tu, Jiapian Huang, Wenlin Xie*, Tonghao Zhu* and Jie Wu*, Generation of (E)-β-sulfonyl enamines from sulfur dioxide via a radical process, Org. Chem. Front., 2021, 8(8), 1789-1794
6. Yanfang Yao, Ziqing Yin, Weiyun Chen, Wenlin Xie,* Fu-Sheng He,* and Jie Wu*, A Concise Route to 2-Sulfonylacetonitriles from Sodium Metabisulfite, Adv. Synth. Catal., 2021, 363(2), 570–574
7. Liangkun Ji, Ying Zhou, Qiuyan Yu, Yaxuan Fang, Yongjun Jiang, Yunhui Zhao, Chuntao Yuan, Wenlin Xie*, Synthesis and anticancer activity of new spirooxindoles incorporating[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine moiety, J. Mol. Struct., 1227 (2021) 129406
8. Renzhi Liu, Min Yang, Wenlin Xie*, Wenbi Dong, Hongwei Zhou, Sarita Yadav, Vladimir Ivano-vich Potkin, Guanyinsheng Qiu*, Synthesis of 3-Hydroxyisoindolin-1-ones Through 1,
4-Dioxane-Mediated Hydroxylhydrative aza-Cyclization of 2-Alkynylbenzamide in Water, J. Org. Chem. , 2020, 85(8), 5312−5320
9. Renzhi Liu, Meng Li, Wenlin Xie*, Hongwei Zhou*, Yajing Zhang, Guanyinsheng Qiu*, Tunable Synthesis of 3-Hydroxylisoquinolin-1, 4-dione and Isoquinolin-1-one Enabled by Copper-Catalyzed Radical 6-Endo Aza-Cyclization of 2-Alkynylbenzamide, J. Org. Chem., 2019, 84(18), 11763−11773
10. Xinxing Gong, Jiahao Chen, Xiaofang Li, Wenlin Xie*,and Jie Wu*, Sulfonylation of Benzylic C-H Bond through a Reaction of Aryl(o-tolyl)methanones with Sulfonyl Hydrazides or Sulfonyl Chlorides, Chem. Asian J., 2018, 13, 2543–2548
11. Wenlin Xie*, Yiqiang Wu, Jingai Zhang, Qihong Mei, Yahan Zhang, Ning Zhu, Renzhi Liu,Huilin Zhang, Design, synthesis and biological evaluations of novel pyridone-thiazole hybrid molecules as antitumor agents, Eur. J. Med. Chem., 2018, 145, 35-40
12. Wenlin Xie*, Huilin Zhang, Jingjing He, Jingai Zhang, Qiuyan Yu, Chunxiang Luo, Shangru Li，Synthesis and Biological Evaluation of novel hydroxybenzaldehyde-based Kojic Acid analogues as inhibitors of mushroom tyrosinase, Bioorg. Med. Chem. Lett., 2017, 27(3): 530-532
13. Wenlin Xie *, Jingai Zhang, Xiaojing Ma, Wenqian Yang, Ying Zhou, Xufu Tang, Yan Zou,Hui Li, Jingjing He, Shimin Xie, Yunhui Zhao, Fengping Liu, Synthesis and Biological Evaluation of Kojic Acid Derivatives Containing 1,2,4-triazole as Potent Tyrosinase Inhibitors,Chem. Biol. Drug. Des., 2015, 86(5): 1087–1092
14. Wenlin Xie*, Shimin Xie, Ying Zhou, Xufu Tang, Jian Liu, Wenqian Yang, Minghua Qiu,Design and synthesis of novel 5,6-disubstituted pyridine-2,3-dione-3-thiosemicarbazone derivatives as potential anticancer agents, Eur. J. Med. Chem., 2014, 81,22-27
15. Wenlin Xie∗, Jian Liu, Minghua Qiu, Jiancheng Yuan, and Anlong Xu, Design, synthesis and biological activity of cell-penetrating peptide-modified octreotide analogs. Journal of peptide scicence, 2010, 16(2): 105-109
奖励荣誉：
1. 谢文林，赵云辉，张慧霖，于贤勇，类天然有机分子的构建及其生物活性研究，湖南省自然科学三等奖，湖南省人民政府，2021年。
2. 科研引领教学，平台支撑实践，构建地方高校创新型化学化工类研究生培养模式, 湖南省高等教育教学成果三等奖，2019年，第三完成人。
专利成果：
1. 谢文林，张慧霖，余秋艳，吴乙强，梅期宏，骆春香，一种含螺吲哚-2-酮衍生物及其制备方法和作为抗癌药物的应用 (ZL201610309985.5)。
2. 谢文林，张金改，余秋艳，何晶晶，李芯蕊，骆春香，李尚儒，柳建斌, 5-取代-3-[5-羟基-4-吡喃酮-2-基-甲硫基]-4-羟基苯甲氨基-1,2,4-**类化合物及其用途 (ZL201510414130.4)。
3. 谢文林，吴乙强，梅期宏，张金改，张慧霖，刘仁志，一种含噻唑环吡啶酮衍生物及其制备方法和应用 (ZL201710435688.X )
4. 谢文林，刘仁志，梅期红, 一种含1,3,4-噻二唑的吲哚酮衍生物、制备方法及应用(ZL201810560144.0)
5. 谢文林，刘仁志，梅期红, 一种含1,3,4-噻二唑新型曲酸衍生物及其应用(ZL201811293631.1)
6. 谢文林，冀良坤，吴乙强，姚燕芳，一种含螺二氢嘧啶衍生物及其制备方法和应用(ZL201910408220.0)
7. 谢文林，刘仁志，邱观音生，一种3-羟基异吲哚-1-酮系列化合物的绿色制备方法(ZL201910954630.5 )
8. 谢文林，齐瑞，唐凌，刘仁志，一种含1,3,4-噻二唑吡啶-2-酮衍生物的制备方法和作为抗癌药物的应用(ZL202011337199.9)
